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[18F]CVN636
- Development stage
- Unknown
- Lead developer
- Center for Addiction and Mental Health
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Positron Emitters → Radiopharmaceuticals, Small Molecules
- Administration
- Intravenous
01
Overview
[18F]CVN636 is a fluorine-18 labeled radiopharmaceutical developed as a positron emission tomography (PET) imaging tracer for neuroimaging of the metabotropic glutamate receptor 7 (mGluR7). It is synthesized from a boronic ester precursor of CVN636, a highly potent and selective mGluR7 positive allosteric modulator (originally identified as an allosteric agonist) developed by Cerevance and Takeda. Preclinical PET imaging of [18F]CVN636 in Sprague-Dawley rats demonstrated rapid brain penetration followed by swift washout and low overall brain uptake, which may limit its utility for in vivo neuroimaging of mGluR7.
- Other names
- [18F]-(S)-2-(4-fluorophenyl)-N-((3S,4S)-4-(methylsulfonyl)chroman-3-yl)propanamide[18F]-(S)-2-(4-fluorophenyl)-N-((3S,4S)-4-(methylsulfonyl)chroman-3-yl)propenamide[18F]CVN-63618F-CVN-636
02
Targets
GRM7 (mGluR7)
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